Combination of NK cells therapy and oral administration of entinostat as an approach for osteosarcoma lung metastasis treatment

Introduction The goal of this study is to find an alternate therapy for osteosarcoma (OS) lung metastasis. Previously we showed that NK cell therapy significantly decreased OS lung metastasis in a mouse model; however, the therapy was not effective enough to cure OS lung metastasis. To augment the NK cell therapy, we elected to combine it with entinostat, an HDAC inhibitor. Studies have shown that HDACis sensitize tumor cells to NK cells cytotoxicity mostly by increasing expression of ligands for NK cells on tumor cells.